Rachel D. Schrier, Saurabh Gupta, Patricia Riggs, Lucette A. Cysique, Scott Letendre, Hua Jin, Stephen A. Spector, Kumud K. Singh, Tanya Wolfson, Zunyou Wu, Kun Xue Hong, Xin Yu, Chuan Shi, Robert K. Heaton

HLA-DR*04 was identified as a predictor of HIV-Associated neurocognitive disorder (HAND), low CD4 T-cell responses to HIV, and low plasma HIV RNA levels in a U.S. cohort. We hypothesized that low CD4 T-cell activation leads to poor immune control of HIV in the CNS, predisposing to HAND, but also provided fewer target (activated CD4 T-cells) for HIV replication. To assess the consistency of these HLA Class II associations in a new cohort and extend analysis to HLA Class I, HLA types, neurocognitive, and virologic status were examined in a cohort of former plasma donors in China.