Title |
Potent Anti-Inflammatory Activity of Ursolic Acid, a Triterpenoid Antioxidant, Is Mediated through Suppression of NF-κB, AP-1 and NF-AT
|
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Published in |
PLOS ONE, February 2012
|
DOI | 10.1371/journal.pone.0031318 |
Pubmed ID | |
Authors |
Rahul Checker, Santosh K. Sandur, Deepak Sharma, Raghavendra S. Patwardhan, S. Jayakumar, Vineet Kohli, Gautam Sethi, Bharat B. Aggarwal, Krishna B. Sainis |
Abstract |
Ursolic acid (UA), a pentacyclic triterpenoid carboxylic acid, is the major component of many plants including apples, basil, cranberries, peppermint, rosemary, oregano and prunes and has been reported to possess antioxidant and anti-tumor properties. These properties of UA have been attributed to its ability to suppress NF-κB (nuclear factor kappa B) activation. Since NF-κB, in co-ordination with NF-AT (nuclear factor of activated T cells) and AP-1(activator protein-1), is known to regulate inflammatory genes, we hypothesized that UA might exhibit potent anti-inflammatory effects. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 200 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 15% |
Researcher | 21 | 10% |
Student > Master | 21 | 10% |
Student > Doctoral Student | 18 | 9% |
Student > Bachelor | 15 | 7% |
Other | 38 | 19% |
Unknown | 57 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 30 | 15% |
Agricultural and Biological Sciences | 27 | 13% |
Biochemistry, Genetics and Molecular Biology | 21 | 10% |
Medicine and Dentistry | 21 | 10% |
Chemistry | 21 | 10% |
Other | 20 | 10% |
Unknown | 61 | 30% |