| Title |
Multiple Intravenous Administrations of Human Umbilical Cord Blood Cells Benefit in a Mouse Model of ALS
|
|---|---|
| Published in |
PLOS ONE, February 2012
|
| DOI | 10.1371/journal.pone.0031254 |
| Pubmed ID | |
| Authors |
Svitlana Garbuzova-Davis, Maria C. O. Rodrigues, Santhia Mirtyl, Shanna Turner, Shazia Mitha, Jasmine Sodhi, Subatha Suthakaran, David J. Eve, Cyndy D. Sanberg, Nicole Kuzmin-Nichols, Paul R. Sanberg |
| Abstract |
A promising therapeutic strategy for amyotrophic lateral sclerosis (ALS) is the use of cell-based therapies that can protect motor neurons and thereby retard disease progression. We recently showed that a single large dose (25 × 10⁶ cells) of mononuclear cells from human umbilical cord blood (MNC hUCB) administered intravenously to pre-symptomatic G93A SOD1 mice is optimal in delaying disease progression and increasing lifespan. However, this single high cell dose is impractical for clinical use. The aim of the present pre-clinical translation study was therefore to evaluate the effects of multiple low dose systemic injections of MNC hUCB cell into G93A SOD1 mice at different disease stages. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| United Kingdom | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 3% |
| Germany | 1 | 2% |
| United Kingdom | 1 | 2% |
| Unknown | 59 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 24% |
| Student > Bachelor | 12 | 19% |
| Student > Master | 10 | 16% |
| Researcher | 7 | 11% |
| Professor | 3 | 5% |
| Other | 12 | 19% |
| Unknown | 4 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 33% |
| Medicine and Dentistry | 14 | 22% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Neuroscience | 5 | 8% |
| Nursing and Health Professions | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 7 | 11% |