| Title |
Probiotic Bacteria Produce Conjugated Linoleic Acid Locally in the Gut That Targets Macrophage PPAR γ to Suppress Colitis
|
|---|---|
| Published in |
PLOS ONE, February 2012
|
| DOI | 10.1371/journal.pone.0031238 |
| Pubmed ID | |
| Authors |
Josep Bassaganya-Riera, Monica Viladomiu, Mireia Pedragosa, Claudio De Simone, Adria Carbo, Rustem Shaykhutdinov, Christian Jobin, Janelle C. Arthur, Benjamin A. Corl, Hans Vogel, Martin Storr, Raquel Hontecillas |
| Abstract |
Inflammatory bowel disease (IBD) therapies are modestly successful and associated with significant side effects. Thus, the investigation of novel approaches to prevent colitis is important. Probiotic bacteria can produce immunoregulatory metabolites in vitro such as conjugated linoleic acid (CLA), a polyunsaturated fatty acid with potent anti-inflammatory effects. This study aimed to investigate the cellular and molecular mechanisms underlying the anti-inflammatory efficacy of probiotic bacteria using a mouse model of colitis. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 63% |
| Belgium | 1 | 13% |
| Netherlands | 1 | 13% |
| Unknown | 1 | 13% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 170 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 36 | 21% |
| Student > Ph. D. Student | 35 | 20% |
| Student > Master | 21 | 12% |
| Student > Bachelor | 14 | 8% |
| Other | 12 | 7% |
| Other | 33 | 19% |
| Unknown | 24 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 56 | 32% |
| Immunology and Microbiology | 22 | 13% |
| Medicine and Dentistry | 20 | 11% |
| Biochemistry, Genetics and Molecular Biology | 19 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 20 | 11% |
| Unknown | 33 | 19% |