| Title |
A Pilot Study of IL-2Rα Blockade during Lymphopenia Depletes Regulatory T-cells and Correlates with Enhanced Immunity in Patients with Glioblastoma
|
|---|---|
| Published in |
PLOS ONE, February 2012
|
| DOI | 10.1371/journal.pone.0031046 |
| Pubmed ID | |
| Authors |
John H. Sampson, Robert J. Schmittling, Gary E. Archer, Kendra L. Congdon, Smita K. Nair, Elizabeth A. Reap, Annick Desjardins, Allan H. Friedman, Henry S. Friedman, James E. Herndon, April Coan, Roger E. McLendon, David A. Reardon, James J. Vredenburgh, Darell D. Bigner, Duane A. Mitchell |
| Abstract |
Preclinical studies in mice have demonstrated that the prophylactic depletion of immunosuppressive regulatory T-cells (T(Regs)) through targeting the high affinity interleukin-2 (IL-2) receptor (IL-2Rα/CD25) can enhance anti-tumor immunotherapy. However, therapeutic approaches are complicated by the inadvertent inhibition of IL-2Rα expressing anti-tumor effector T-cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| India | 1 | 1% |
| France | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 74 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 21% |
| Student > Ph. D. Student | 11 | 14% |
| Other | 8 | 10% |
| Student > Master | 8 | 10% |
| Student > Bachelor | 7 | 9% |
| Other | 12 | 15% |
| Unknown | 16 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 29% |
| Agricultural and Biological Sciences | 12 | 15% |
| Biochemistry, Genetics and Molecular Biology | 8 | 10% |
| Immunology and Microbiology | 6 | 8% |
| Neuroscience | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 18 | 23% |