| Title |
Progesterone Inhibits Epithelial-to-Mesenchymal Transition in Endometrial Cancer
|
|---|---|
| Published in |
PLOS ONE, January 2012
|
| DOI | 10.1371/journal.pone.0030840 |
| Pubmed ID | |
| Authors |
Paul H. van der Horst, Yongyi Wang, Ingrid Vandenput, Liesbeth C. Kühne, Patricia C. Ewing, Wilfred F. J. van IJcken, Marten van der Zee, Frederic Amant, Curt W. Burger, Leen J. Blok |
| Abstract |
Every year approximately 74,000 women die of endometrial cancer, mainly due to recurrent or metastatic disease. The presence of tumor infiltrating lymphocytes (TILs) as well as progesterone receptor (PR) positivity has been correlated with improved prognosis. This study describes two mechanisms by which progesterone inhibits metastatic spread of endometrial cancer: by stimulating T-cell infiltration and by inhibiting epithelial-to-mesenchymal cell transition (EMT). |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Hong Kong | 1 | 2% |
| Unknown | 53 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 31% |
| Student > Master | 9 | 16% |
| Professor > Associate Professor | 7 | 13% |
| Student > Doctoral Student | 6 | 11% |
| Student > Bachelor | 6 | 11% |
| Other | 7 | 13% |
| Unknown | 3 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 42% |
| Agricultural and Biological Sciences | 10 | 18% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Engineering | 2 | 4% |
| Social Sciences | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 10 | 18% |