| Title |
Kinin-B2 Receptor Mediated Neuroprotection after NMDA Excitotoxicity Is Reversed in the Presence of Kinin-B1 Receptor Agonists
|
|---|---|
| Published in |
PLOS ONE, February 2012
|
| DOI | 10.1371/journal.pone.0030755 |
| Pubmed ID | |
| Authors |
Antonio H. Martins, Janaina M. Alves, Dinely Perez, Marimeé Carrasco, Wilmarie Torres-Rivera, Vesna A. Eterović, Pedro A. Ferchmin, Henning Ulrich |
| Abstract |
Kinins, with bradykinin and des-Arg(9)-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke. Although the actions of bradykinin are in general well characterized; it remains controversial whether the effects of bradykinin are beneficial or not. Kinin-B2 receptor activation participates in various physiological processes including hypotension, neurotransmission and neuronal differentiation. The bradykinin metabolite des-Arg(9)-bradykinin as well as Lys-des-Arg(9)-bradykinin activates the kinin-B1 receptor known to be expressed under inflammatory conditions. We have investigated the effects of kinin-B1 and B2 receptor activation on N-methyl-D-aspartate (NMDA)-induced excitotoxicity measured as decreased capacity to produce synaptically evoked population spikes in the CA1 area of rat hippocampal slices. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 34% |
| Student > Master | 6 | 15% |
| Researcher | 4 | 10% |
| Professor | 3 | 7% |
| Student > Bachelor | 3 | 7% |
| Other | 10 | 24% |
| Unknown | 1 | 2% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 46% |
| Biochemistry, Genetics and Molecular Biology | 8 | 20% |
| Neuroscience | 6 | 15% |
| Medicine and Dentistry | 2 | 5% |
| Sports and Recreations | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 3 | 7% |