Title |
Activation of PKCzeta and PKMzeta in the Nucleus Accumbens Core Is Necessary for the Retrieval, Consolidation and Reconsolidation of Drug Memory
|
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Published in |
PLOS ONE, February 2012
|
DOI | 10.1371/journal.pone.0030502 |
Pubmed ID | |
Authors |
Jose A. Crespo, Petra Stöckl, Florian Ueberall, Marcel Jenny, Alois Saria, Gerald Zernig |
Abstract |
One of the greatest challenges in the treatment of substance dependence is to reverse the control that drug-associated stimuli have gained over the addict's behavior, as these drug-associated memories increase the risk of relapse even after long periods of abstinence. We report here that inhibition of the atypical protein kinase C isoform PKCzeta and its constitutively active isoform PKMzeta with the pseudosubstrate inhibitor ZIP administered locally into the nucleus accumbens core reversibly inhibited the retrieval of drug-associated memory and drug (remifentanil) seeking, whereas a scrambled ZIP peptide or staurosporine, an effective inhibitor of c/nPKC-, CaMKII-, and PKA kinases that does not affect PKCzeta/PKMzeta activity, was without effect on these memory processes. Acquisition or extinction of drug-associated memory remained unaffected by PKCzeta- and PKMzeta inhibition. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 3% |
Unknown | 61 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 12 | 19% |
Student > Ph. D. Student | 10 | 16% |
Researcher | 9 | 14% |
Student > Bachelor | 6 | 10% |
Professor > Associate Professor | 5 | 8% |
Other | 14 | 22% |
Unknown | 7 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 30% |
Neuroscience | 13 | 21% |
Psychology | 11 | 17% |
Medicine and Dentistry | 4 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Other | 5 | 8% |
Unknown | 9 | 14% |