| Title |
Endothelial Progenitor Cells (EPCs) as Gene Carrier System for Rat Model of Human Glioma
|
|---|---|
| Published in |
PLOS ONE, January 2012
|
| DOI | 10.1371/journal.pone.0030310 |
| Pubmed ID | |
| Authors |
Nadimpalli Ravi S. Varma, Branislava Janic, A. S. M. Iskander, Adarsh Shankar, Mohammed P. I. Bhuiyan, Hamid Soltanian-Zadeh, Quan Jiang, Kenneth Barton, Meser M. Ali, Ali S. Arbab |
| Abstract |
Due to their unique property to migrate to pathological lesions, stem cells are used as a delivery vehicle for therapeutic genes to tumors, especially for glioma. It is critically important to track the movement, localization, engraftment efficiency and functional capability or expression of transgenes of selected cell populations following transplantation. The purposes of this study were to investigate whether 1) intravenously administered, genetically transformed cord blood derived EPCs can carry human sodium iodide symporter (hNIS) to the sites of tumors in rat orthotopic model of human glioma and express transgene products, and 2) whether accumulation of these administered EPCs can be tracked by different in vivo imaging modalities. |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 20% |
| Student > Bachelor | 2 | 20% |
| Researcher | 2 | 20% |
| Student > Master | 2 | 20% |
| Unknown | 2 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 30% |
| Agricultural and Biological Sciences | 2 | 20% |
| Biochemistry, Genetics and Molecular Biology | 1 | 10% |
| Physics and Astronomy | 1 | 10% |
| Neuroscience | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 2 | 20% |