Title |
Evaluation of a Previously Suggested Plasma Biomarker Panel to Identify Alzheimer's Disease
|
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Published in |
PLOS ONE, January 2012
|
DOI | 10.1371/journal.pone.0029868 |
Pubmed ID | |
Authors |
Maria Björkqvist, Mattias Ohlsson, Lennart Minthon, Oskar Hansson |
Abstract |
There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDGF-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Sweden | 1 | <1% |
France | 1 | <1% |
Belgium | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 121 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 30 | 24% |
Student > Ph. D. Student | 25 | 20% |
Student > Master | 16 | 13% |
Student > Bachelor | 15 | 12% |
Other | 7 | 6% |
Other | 13 | 10% |
Unknown | 21 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 24% |
Medicine and Dentistry | 16 | 13% |
Neuroscience | 14 | 11% |
Biochemistry, Genetics and Molecular Biology | 14 | 11% |
Chemistry | 7 | 6% |
Other | 22 | 17% |
Unknown | 23 | 18% |