| Title |
Amyloid-Mediated Sequestration of Essential Proteins Contributes to Mutant Huntingtin Toxicity in Yeast
|
|---|---|
| Published in |
PLOS ONE, January 2012
|
| DOI | 10.1371/journal.pone.0029832 |
| Pubmed ID | |
| Authors |
Natalia V. Kochneva-Pervukhova, Alexander I. Alexandrov, Michael D. Ter-Avanesyan |
| Abstract |
Polyglutamine expansion is responsible for several neurodegenerative disorders, among which Huntington disease is the most well-known. Studies in the yeast model demonstrated that both aggregation and toxicity of a huntingtin (htt) protein with an expanded polyglutamine region strictly depend on the presence of the prion form of Rnq1 protein ([PIN+]), which has a glutamine/asparagine-rich domain. |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 2% |
| Israel | 1 | 2% |
| Canada | 1 | 2% |
| Korea, Republic of | 1 | 2% |
| Russia | 1 | 2% |
| Unknown | 60 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 31% |
| Researcher | 16 | 25% |
| Student > Bachelor | 6 | 9% |
| Student > Master | 6 | 9% |
| Professor | 3 | 5% |
| Other | 8 | 12% |
| Unknown | 6 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 46% |
| Biochemistry, Genetics and Molecular Biology | 20 | 31% |
| Chemistry | 2 | 3% |
| Computer Science | 1 | 2% |
| Psychology | 1 | 2% |
| Other | 4 | 6% |
| Unknown | 7 | 11% |