| Title |
The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer
|
|---|---|
| Published in |
PLOS ONE, January 2012
|
| DOI | 10.1371/journal.pone.0029783 |
| Pubmed ID | |
| Authors |
Tingxiu Xiang, Lili Li, Xuedong Yin, Chenfu Yuan, Cui Tan, Xianwei Su, Lei Xiong, Thomas C. Putti, Michael Oberst, Kathleen Kelly, Guosheng Ren, Qian Tao |
| Abstract |
Breast cancer (BrCa) is a complex disease driven by aberrant gene alterations and environmental factors. Recent studies reveal that abnormal epigenetic gene regulation also plays an important role in its pathogenesis. Ubiquitin carboxyl- terminal esterase L1 (UCHL1) is a tumor suppressor silenced by promoter methylation in multiple cancers, but its role and alterations in breast tumorigenesis remain unclear. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | 2% |
| South Africa | 1 | 2% |
| Unknown | 61 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 22% |
| Researcher | 14 | 22% |
| Student > Master | 9 | 14% |
| Student > Bachelor | 6 | 10% |
| Student > Doctoral Student | 4 | 6% |
| Other | 5 | 8% |
| Unknown | 11 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 30% |
| Biochemistry, Genetics and Molecular Biology | 10 | 16% |
| Chemistry | 8 | 13% |
| Medicine and Dentistry | 7 | 11% |
| Immunology and Microbiology | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 12 | 19% |