Title |
Characterization of the Endothelial Cell Cytoskeleton following HLA Class I Ligation
|
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Published in |
PLOS ONE, January 2012
|
DOI | 10.1371/journal.pone.0029472 |
Pubmed ID | |
Authors |
Mary E. Ziegler, Puneet Souda, Yi-Ping Jin, Julian P. Whitelegge, Elaine F. Reed |
Abstract |
Vascular endothelial cells (ECs) are a target of antibody-mediated allograft rejection. In vitro, when the HLA class I molecules on the surface of ECs are ligated by anti-HLA class I antibodies, cell proliferation and survival pathways are activated and this is thought to contribute to the development of antibody-mediated rejection. Crosslinking of HLA class I molecules by anti-HLA antibodies also triggers reorganization of the cytoskeleton, which induces the formation of F-actin stress fibers. HLA class I induced stress fiber formation is not well understood. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 17% |
Student > Ph. D. Student | 5 | 17% |
Student > Master | 4 | 13% |
Other | 3 | 10% |
Student > Doctoral Student | 3 | 10% |
Other | 6 | 20% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 30% |
Medicine and Dentistry | 6 | 20% |
Immunology and Microbiology | 2 | 7% |
Engineering | 2 | 7% |
Neuroscience | 2 | 7% |
Other | 4 | 13% |
Unknown | 5 | 17% |