| Title |
In Vivo Tracking of Human Neural Stem Cells with 19F Magnetic Resonance Imaging
|
|---|---|
| Published in |
PLOS ONE, December 2011
|
| DOI | 10.1371/journal.pone.0029040 |
| Pubmed ID | |
| Authors |
Philipp Boehm-Sturm, Luam Mengler, Stefan Wecker, Mathias Hoehn, Therése Kallur |
| Abstract |
Magnetic resonance imaging (MRI) is a promising tool for monitoring stem cell-based therapy. Conventionally, cells loaded with ironoxide nanoparticles appear hypointense on MR images. However, the contrast generated by ironoxide labeled cells is neither specific due to ambiguous background nor quantitative. A strategy to overcome these drawbacks is (19)F MRI of cells labeled with perfluorocarbons. We show here for the first time that human neural stem cells (NSCs), a promising candidate for clinical translation of stem cell-based therapy of the brain, can be labeled with (19)F as well as detected and quantified in vitro and after brain implantation. |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 3% |
| Japan | 2 | 2% |
| Switzerland | 1 | <1% |
| Portugal | 1 | <1% |
| Russia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 93 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 25% |
| Student > Ph. D. Student | 25 | 25% |
| Student > Master | 15 | 15% |
| Student > Doctoral Student | 8 | 8% |
| Student > Bachelor | 6 | 6% |
| Other | 16 | 16% |
| Unknown | 6 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 21% |
| Medicine and Dentistry | 13 | 13% |
| Engineering | 12 | 12% |
| Chemistry | 11 | 11% |
| Physics and Astronomy | 9 | 9% |
| Other | 25 | 25% |
| Unknown | 11 | 11% |