| Title |
Two Lysines in the Forkhead Domain of Foxp3 Are Key to T Regulatory Cell Function
|
|---|---|
| Published in |
PLOS ONE, January 2012
|
| DOI | 10.1371/journal.pone.0029035 |
| Pubmed ID | |
| Authors |
Yujie Liu, Liqing Wang, Rongxiang Han, Ulf H. Beier, Wayne W. Hancock |
| Abstract |
The forkhead box transcription factor, Foxp3, is master regulator of the development and function of CD4+CD25+ T regulatory (Treg) cells that limit autoimmunity and maintain immune homeostasis. The carboxyl-terminal forkhead (FKH) domain is required for the nuclear localization and DNA binding of Foxp3. We assessed how individual FKH lysines contribute to the functions of Foxp3 in Treg cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 21% |
| Student > Ph. D. Student | 6 | 15% |
| Student > Bachelor | 6 | 15% |
| Other | 3 | 8% |
| Student > Master | 3 | 8% |
| Other | 8 | 21% |
| Unknown | 5 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 41% |
| Biochemistry, Genetics and Molecular Biology | 7 | 18% |
| Immunology and Microbiology | 4 | 10% |
| Medicine and Dentistry | 3 | 8% |
| Unspecified | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 7 | 18% |