| Title |
Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
|
|---|---|
| Published in |
PLOS ONE, December 2011
|
| DOI | 10.1371/journal.pone.0028668 |
| Pubmed ID | |
| Authors |
Giuseppe Esposito, Caterina Scuderi, Marta Valenza, Giuseppina Ines Togna, Valentina Latina, Daniele De Filippis, Mariateresa Cipriano, Maria Rosaria Carratù, Teresa Iuvone, Luca Steardo |
| Abstract |
Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to be involved in the etiology of pathological features of Alzheimer's disease (AD). Cannabidiol (CBD), a Cannabis derivative devoid of psychomimetic effects, has attracted much attention because of its promising neuroprotective properties in rat AD models, even though the mechanism responsible for such actions remains unknown. This study was aimed at exploring whether CBD effects could be subordinate to its activity at PPARγ, which has been recently indicated as its putative binding site. CBD actions on β-amyloid-induced neurotoxicity in rat AD models, either in presence or absence of PPAR antagonists were investigated. Results showed that the blockade of PPARγ was able to significantly blunt CBD effects on reactive gliosis and subsequently on neuronal damage. Moreover, due to its interaction at PPARγ, CBD was observed to stimulate hippocampal neurogenesis. All these findings report the inescapable role of this receptor in mediating CBD actions, here reported. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 14% |
| United Kingdom | 2 | 9% |
| Canada | 2 | 9% |
| Unknown | 15 | 68% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 95% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 428 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| United States | 2 | <1% |
| Spain | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 421 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 73 | 17% |
| Student > Master | 56 | 13% |
| Researcher | 49 | 11% |
| Student > Ph. D. Student | 47 | 11% |
| Other | 20 | 5% |
| Other | 59 | 14% |
| Unknown | 124 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 55 | 13% |
| Agricultural and Biological Sciences | 52 | 12% |
| Medicine and Dentistry | 40 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 38 | 9% |
| Biochemistry, Genetics and Molecular Biology | 35 | 8% |
| Other | 71 | 17% |
| Unknown | 137 | 32% |