| Title |
Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure
|
|---|---|
| Published in |
PLOS ONE, December 2011
|
| DOI | 10.1371/journal.pone.0028632 |
| Pubmed ID | |
| Authors |
Jairam R. Lingappa, Slavé Petrovski, Erin Kahle, Jacques Fellay, Kevin Shianna, M. Juliana McElrath, Katherine K. Thomas, Jared M. Baeten, Connie Celum, Anna Wald, Guy de Bruyn, James I. Mullins, Edith Nakku-Joloba, Carey Farquhar, Max Essex, Deborah Donnell, James Kiarie, Bart Haynes, David Goldstein, for the Partners in Prevention HSV/HIV Transmission Study Team |
| Abstract |
Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the context of a cohort of African HIV-1 serodiscordant heterosexual couples. To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| India | 1 | 1% |
| South Africa | 1 | 1% |
| Japan | 1 | 1% |
| Argentina | 1 | 1% |
| Unknown | 86 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 21% |
| Student > Master | 16 | 17% |
| Student > Bachelor | 11 | 12% |
| Student > Ph. D. Student | 9 | 10% |
| Professor | 9 | 10% |
| Other | 22 | 24% |
| Unknown | 6 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 33% |
| Medicine and Dentistry | 21 | 23% |
| Biochemistry, Genetics and Molecular Biology | 11 | 12% |
| Social Sciences | 5 | 5% |
| Immunology and Microbiology | 5 | 5% |
| Other | 9 | 10% |
| Unknown | 11 | 12% |