| Title |
Vaccination with M2e-Based Multiple Antigenic Peptides: Characterization of the B Cell Response and Protection Efficacy in Inbred and Outbred Mice
|
|---|---|
| Published in |
PLOS ONE, December 2011
|
| DOI | 10.1371/journal.pone.0028445 |
| Pubmed ID | |
| Authors |
Amaya I. Wolf, Krystyna Mozdzanowska, Katie L. Williams, David Singer, Monique Richter, Ralf Hoffmann, Andrew J. Caton, Laszlo Otvos, Jan Erikson |
| Abstract |
The extracellular domain of the influenza A virus protein matrix protein 2 (M2e) is remarkably conserved between various human isolates and thus is a viable target antigen for a universal influenza vaccine. With the goal of inducing protection in multiple mouse haplotypes, M2e-based multiple antigenic peptides (M2e-MAP) were synthesized to contain promiscuous T helper determinants from the Plasmodium falciparum circumsporozoite protein, the hepatitis B virus antigen and the influenza virus hemagglutinin. Here, we investigated the nature of the M2e-MAP-induced B cell response in terms of the distribution of antibody (Ab) secreting cells (ASCs) and Ab isotypes, and tested the protective efficacy in various mouse strains. |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 2% |
| Unknown | 52 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 30% |
| Researcher | 15 | 28% |
| Student > Master | 7 | 13% |
| Student > Doctoral Student | 5 | 9% |
| Student > Bachelor | 4 | 8% |
| Other | 0 | 0% |
| Unknown | 6 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 30% |
| Biochemistry, Genetics and Molecular Biology | 9 | 17% |
| Immunology and Microbiology | 8 | 15% |
| Medicine and Dentistry | 7 | 13% |
| Chemistry | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 7 | 13% |