| Title |
Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases
|
|---|---|
| Published in |
PLOS ONE, November 2011
|
| DOI | 10.1371/journal.pone.0027970 |
| Pubmed ID | |
| Authors |
Xiaotun Zhang, Colm Morrissey, Shihua Sun, Melanie Ketchandji, Peter S. Nelson, Lawrence D. True, Funda Vakar-Lopez, Robert L. Vessella, Stephen R. Plymate |
| Abstract |
Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated genes. We recently reported that C-terminal truncated constitutively active AR splice variants contribute to CRPC development. Since specific antibodies detecting all C-terminal truncated AR variants are not available, our aim was to develop an approach to assess the prevalence and function of AR variants in prostate cancer (PCa). |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Italy | 1 | <1% |
| Uruguay | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 97 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 22% |
| Student > Ph. D. Student | 20 | 19% |
| Student > Master | 11 | 11% |
| Other | 8 | 8% |
| Professor > Associate Professor | 7 | 7% |
| Other | 21 | 20% |
| Unknown | 14 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 31% |
| Agricultural and Biological Sciences | 28 | 27% |
| Biochemistry, Genetics and Molecular Biology | 22 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Immunology and Microbiology | 1 | <1% |
| Other | 3 | 3% |
| Unknown | 16 | 15% |