| Title |
No Evidence for XMRV Nucleic Acids, Infectious Virus or Anti-XMRV Antibodies in Canadian Patients with Chronic Fatigue Syndrome
|
|---|---|
| Published in |
PLOS ONE, November 2011
|
| DOI | 10.1371/journal.pone.0027870 |
| Pubmed ID | |
| Authors |
Imke Steffen, D. Lorne Tyrrell, Eleanor Stein, Leilani Montalvo, Tzong-Hae Lee, Yanchen Zhou, Kai Lu, William M. Switzer, Shaohua Tang, Hongwei Jia, Darren Hockman, Deanna M. Santer, Michael Logan, Amir Landi, John Law, Michael Houghton, Graham Simmons |
| Abstract |
The gammaretroviruses xenotropic murine leukemia virus (MLV)-related virus (XMRV) and MLV have been reported to be more prevalent in plasma and peripheral blood mononuclear cells of chronic fatigue syndrome (CFS) patients than in healthy controls. Here, we report the complex analysis of whole blood and plasma samples from 58 CFS patients and 57 controls from Canada for the presence of XMRV/MLV nucleic acids, infectious virus, and XMRV/MLV-specific antibodies. Multiple techniques were employed, including nested and qRT-PCR, cell culture, and immunoblotting. We found no evidence of XMRV or MLV in humans and conclude that CFS is not associated with these gammaretroviruses. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 14% |
| Unknown | 6 | 86% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 5% |
| Unknown | 19 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 25% |
| Student > Doctoral Student | 3 | 15% |
| Other | 2 | 10% |
| Professor | 2 | 10% |
| Student > Bachelor | 1 | 5% |
| Other | 4 | 20% |
| Unknown | 3 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 35% |
| Agricultural and Biological Sciences | 4 | 20% |
| Nursing and Health Professions | 2 | 10% |
| Social Sciences | 2 | 10% |
| Psychology | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 4 | 20% |