| Title |
Loss of Keratin 8 Phosphorylation Leads to Increased Tumor Progression and Correlates with Clinico-Pathological Parameters of OSCC Patients
|
|---|---|
| Published in |
PLOS ONE, November 2011
|
| DOI | 10.1371/journal.pone.0027767 |
| Pubmed ID | |
| Authors |
Hunain Alam, Prakash Gangadaran, Amruta V. Bhate, Devendra A. Chaukar, Sharada S. Sawant, Richa Tiwari, Jyoti Bobade, Sadhana Kannan, Anil K. D'cruz, Shubhada Kane, Milind M. Vaidya |
| Abstract |
Keratins are cytoplasmic intermediate filament proteins expressed in tissue specific and differentiation dependent manner. Keratins 8 and 18 (K8 and K18) are predominantly expressed in simple epithelial tissues and perform both mechanical and regulatory functions. Aberrant expression of K8 and K18 is associated with neoplastic progression, invasion and poor prognosis in human oral squamous cell carcinomas (OSCCs). K8 and K18 undergo several post-translational modifications including phosphorylation, which are known to regulate their functions in various cellular processes. Although, K8 and K18 phosphorylation is known to regulate cell cycle, cell growth and apoptosis, its significance in cell migration and/or neoplastic progression is largely unknown. In the present study we have investigated the role of K8 phosphorylation in cell migration and/or neoplastic progression in OSCC. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 1 | 2% |
| Unknown | 52 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 25% |
| Researcher | 7 | 13% |
| Student > Master | 6 | 11% |
| Student > Bachelor | 5 | 9% |
| Student > Doctoral Student | 4 | 8% |
| Other | 10 | 19% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 36% |
| Biochemistry, Genetics and Molecular Biology | 9 | 17% |
| Medicine and Dentistry | 7 | 13% |
| Engineering | 3 | 6% |
| Physics and Astronomy | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 8 | 15% |