| Title |
Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells
|
|---|---|
| Published in |
PLOS ONE, November 2011
|
| DOI | 10.1371/journal.pone.0027265 |
| Pubmed ID | |
| Authors |
Arpita Konar, Navjot Shah, Rumani Singh, Nishant Saxena, Sunil C. Kaul, Renu Wadhwa, Mahendra K. Thakur |
| Abstract |
Scopolamine is a well-known cholinergic antagonist that causes amnesia in human and animal models. Scopolamine-induced amnesia in rodent models has been widely used to understand the molecular, biochemical, behavioral changes, and to delineate therapeutic targets of memory impairment. Although this has been linked to the decrease in central cholinergic neuronal activity following the blockade of muscarinic receptors, the underlying molecular and cellular mechanism(s) particularly the effect on neuroplasticity remains elusive. In the present study, we have investigated (i) the effects of scopolamine on the molecules involved in neuronal and glial plasticity both in vivo and in vitro and (ii) their recovery by alcoholic extract of Ashwagandha leaves (i-Extract). |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 2 | 1% |
| Spain | 1 | <1% |
| Unknown | 136 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 19% |
| Researcher | 19 | 14% |
| Student > Master | 15 | 11% |
| Student > Doctoral Student | 9 | 6% |
| Student > Bachelor | 8 | 6% |
| Other | 26 | 19% |
| Unknown | 36 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 16% |
| Medicine and Dentistry | 15 | 11% |
| Neuroscience | 13 | 9% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 7% |
| Other | 23 | 17% |
| Unknown | 45 | 32% |