Title |
Calcium-Based Nanoparticles Accelerate Skin Wound Healing
|
---|---|
Published in |
PLOS ONE, November 2011
|
DOI | 10.1371/journal.pone.0027106 |
Pubmed ID | |
Authors |
Kenichiro Kawai, Barrett J. Larson, Hisako Ishise, Antoine Lyonel Carre, Soh Nishimoto, Michael Longaker, H. Peter Lorenz |
Abstract |
Nanoparticles (NPs) are small entities that consist of a hydroxyapatite core, which can bind ions, proteins, and other organic molecules from the surrounding environment. These small conglomerations can influence environmental calcium levels and have the potential to modulate calcium homeostasis in vivo. Nanoparticles have been associated with various calcium-mediated disease processes, such as atherosclerosis and kidney stone formation. We hypothesized that nanoparticles could have an effect on other calcium-regulated processes, such as wound healing. In the present study, we synthesized pH-sensitive calcium-based nanoparticles and investigated their ability to enhance cutaneous wound repair. |
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Mendeley readers
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