| Title |
Excess Circulating Alternatively Activated Myeloid (M2) Cells Accelerate ALS Progression While Inhibiting Experimental Autoimmune Encephalomyelitis
|
|---|---|
| Published in |
PLOS ONE, November 2011
|
| DOI | 10.1371/journal.pone.0026921 |
| Pubmed ID | |
| Authors |
Ilan Vaknin, Gilad Kunis, Omer Miller, Oleg Butovsky, Shay Bukshpan, David R. Beers, Jenny S. Henkel, Eti Yoles, Stanley H. Appel, Michal Schwartz |
| Abstract |
Circulating immune cells including autoreactive T cells and monocytes have been documented as key players in maintaining, protecting and repairing the central nervous system (CNS) in health and disease. Here, we hypothesized that neurodegenerative diseases might be associated, similarly to tumors, with increased levels of circulating peripheral myeloid derived suppressor cells (MDSCs), representing a subset of suppressor cells that often expand under pathological conditions and inhibit possible recruitment of helper T cells needed for fighting off the disease. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Serbia | 1 | 1% |
| Unknown | 82 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 24% |
| Student > Ph. D. Student | 19 | 22% |
| Student > Master | 9 | 11% |
| Student > Bachelor | 7 | 8% |
| Student > Doctoral Student | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 14 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 33% |
| Neuroscience | 18 | 21% |
| Medicine and Dentistry | 10 | 12% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Immunology and Microbiology | 2 | 2% |
| Other | 7 | 8% |
| Unknown | 13 | 15% |