Title |
A Genome-Wide Survey on Basic Helix-Loop-Helix Transcription Factors in Giant Panda
|
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Published in |
PLOS ONE, November 2011
|
DOI | 10.1371/journal.pone.0026878 |
Pubmed ID | |
Authors |
Chunwang Dang, Yong Wang, Debao Zhang, Qin Yao, Keping Chen |
Abstract |
The giant panda (Ailuropoda melanoleuca) is a critically endangered mammalian species. Studies on functions of regulatory proteins involved in developmental processes would facilitate understanding of specific behavior in giant panda. The basic helix-loop-helix (bHLH) proteins play essential roles in a wide range of developmental processes in higher organisms. bHLH family members have been identified in over 20 organisms, including fruit fly, zebrafish, mouse and human. Our present study identified 107 bHLH family members being encoded in giant panda genome. Phylogenetic analyses revealed that they belong to 44 bHLH families with 46, 25, 15, 4, 11 and 3 members in group A, B, C, D, E and F, respectively, while the remaining 3 members were assigned into "orphan". Compared to mouse, the giant panda does not encode seven bHLH proteins namely Beta3a, Mesp2, Sclerax, S-Myc, Hes5 (or Hes6), EBF4 and Orphan 1. These results provide useful background information for future studies on structure and function of bHLH proteins in the regulation of giant panda development. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 2% |
Colombia | 1 | <1% |
United Arab Emirates | 1 | <1% |
Turkey | 1 | <1% |
Portugal | 1 | <1% |
India | 1 | <1% |
United Kingdom | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Japan | 1 | <1% |
Other | 0 | 0% |
Unknown | 92 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 20% |
Student > Ph. D. Student | 16 | 16% |
Student > Master | 15 | 15% |
Other | 12 | 12% |
Student > Bachelor | 10 | 10% |
Other | 17 | 17% |
Unknown | 12 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 58 | 57% |
Environmental Science | 17 | 17% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Medicine and Dentistry | 2 | 2% |
Earth and Planetary Sciences | 2 | 2% |
Other | 4 | 4% |
Unknown | 15 | 15% |