Title |
Identification and Characterisation of an Iron-Responsive Candidate Probiotic
|
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Published in |
PLOS ONE, October 2011
|
DOI | 10.1371/journal.pone.0026507 |
Pubmed ID | |
Authors |
Jennifer R. Bailey, Christopher S. J. Probert, Tristan A. Cogan |
Abstract |
Iron is an essential cofactor in almost all biological systems. The lactic acid bacteria (LAB), frequently employed as probiotics, are unusual in having little or no requirement for iron. Iron in the human body is sequestered by transferrins and lactoferrin, limiting bacterial growth. An increase in the availability of iron in the intestine by bleeding, surgery, or under stress leads to an increase in the growth and virulence of many pathogens. Under these high iron conditions, LAB are rapidly out-competed; for the levels of probiotic bacteria to be maintained under high iron conditions they must be able to respond by increasing growth rate to compete with the normal flora. Despite this, iron-responsive genera are poorly characterised as probiotics. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 2 | 3% |
United Kingdom | 1 | 2% |
United States | 1 | 2% |
South Africa | 1 | 2% |
Unknown | 56 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 17 | 28% |
Student > Ph. D. Student | 9 | 15% |
Other | 7 | 11% |
Student > Bachelor | 5 | 8% |
Student > Master | 5 | 8% |
Other | 10 | 16% |
Unknown | 8 | 13% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 25 | 41% |
Medicine and Dentistry | 9 | 15% |
Immunology and Microbiology | 8 | 13% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Chemistry | 3 | 5% |
Other | 3 | 5% |
Unknown | 8 | 13% |