| Title |
Hippocampal CA3 Transcriptome Signature Correlates with Initial Precipitating Injury in Refractory Mesial Temporal Lobe Epilepsy
|
|---|---|
| Published in |
PLOS ONE, October 2011
|
| DOI | 10.1371/journal.pone.0026268 |
| Pubmed ID | |
| Authors |
Silvia Y. Bando, Maryana C. Alegro, Edson Amaro, Alexandre V. Silva, Luiz H. M. Castro, Hung-Tzu Wen, Leandro de A. Lima, Helena Brentani, Carlos Alberto Moreira-Filho |
| Abstract |
Prolonged febrile seizures constitute an initial precipitating injury (IPI) commonly associated with refractory mesial temporal lobe epilepsy (RMTLE). In order to investigate IPI influence on the transcriptional phenotype underlying RMTLE we comparatively analyzed the transcriptomic signatures of CA3 explants surgically obtained from RMTLE patients with (FS) or without (NFS) febrile seizure history. Texture analyses on MRI images of dentate gyrus were conducted in a subset of surgically removed sclerotic hippocampi for identifying IPI-associated histo-radiological alterations. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 4% |
| India | 1 | 1% |
| Belgium | 1 | 1% |
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Luxembourg | 1 | 1% |
| Unknown | 67 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 17% |
| Researcher | 13 | 17% |
| Student > Master | 8 | 11% |
| Other | 7 | 9% |
| Student > Doctoral Student | 6 | 8% |
| Other | 12 | 16% |
| Unknown | 16 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 25% |
| Medicine and Dentistry | 16 | 21% |
| Neuroscience | 12 | 16% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Psychology | 3 | 4% |
| Other | 4 | 5% |
| Unknown | 15 | 20% |