| Title |
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
|
|---|---|
| Published in |
PLOS ONE, September 2011
|
| DOI | 10.1371/journal.pone.0025788 |
| Pubmed ID | |
| Authors |
Naoki Yahata, Masashi Asai, Shiho Kitaoka, Kazutoshi Takahashi, Isao Asaka, Hiroyuki Hioki, Takeshi Kaneko, Kei Maruyama, Takaomi C. Saido, Tatsutoshi Nakahata, Takashi Asada, Shinya Yamanaka, Nobuhisa Iwata, Haruhisa Inoue |
| Abstract |
Alzheimer's disease (AD) is a neurodegenerative disorder that causes progressive memory and cognitive decline during middle to late adult life. The AD brain is characterized by deposition of amyloid β peptide (Aβ), which is produced from amyloid precursor protein by β- and γ-secretase (presenilin complex)-mediated sequential cleavage. Induced pluripotent stem (iPS) cells potentially provide an opportunity to generate a human cell-based model of AD that would be crucial for drug discovery as well as for investigating mechanisms of the disease. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Chile | 1 | 25% |
| Canada | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 266 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 2% |
| Spain | 2 | <1% |
| Japan | 2 | <1% |
| Brazil | 1 | <1% |
| Singapore | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Denmark | 1 | <1% |
| Hungary | 1 | <1% |
| Argentina | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 251 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 51 | 19% |
| Student > Ph. D. Student | 49 | 18% |
| Student > Master | 40 | 15% |
| Student > Bachelor | 31 | 12% |
| Student > Postgraduate | 15 | 6% |
| Other | 53 | 20% |
| Unknown | 27 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 92 | 35% |
| Medicine and Dentistry | 37 | 14% |
| Biochemistry, Genetics and Molecular Biology | 35 | 13% |
| Neuroscience | 35 | 13% |
| Engineering | 8 | 3% |
| Other | 20 | 8% |
| Unknown | 39 | 15% |