| Title |
Notch Ankyrin Repeat Domain Variation Influences Leukemogenesis and Myc Transactivation
|
|---|---|
| Published in |
PLOS ONE, October 2011
|
| DOI | 10.1371/journal.pone.0025645 |
| Pubmed ID | |
| Authors |
Jon C. Aster, Nick Bodnar, Lanwei Xu, Fredrick Karnell, John M. Milholland, Ivan Maillard, Gavin Histen, Yunsun Nam, Stephen C. Blacklow, Warren S. Pear |
| Abstract |
The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1-4 to support T cell development, induce T cell acute lymphoblastic leukemia/lymphoma (T-ALL), and maintain T-ALL cell growth and survival. |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 3% |
| China | 1 | 3% |
| Unknown | 36 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 29% |
| Researcher | 8 | 21% |
| Student > Bachelor | 4 | 11% |
| Student > Master | 4 | 11% |
| Student > Doctoral Student | 2 | 5% |
| Other | 6 | 16% |
| Unknown | 3 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 39% |
| Biochemistry, Genetics and Molecular Biology | 10 | 26% |
| Medicine and Dentistry | 5 | 13% |
| Immunology and Microbiology | 3 | 8% |
| Unspecified | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 3 | 8% |