| Title |
Impaired CD4 T Cell Memory Response to Streptococcus pneumoniae Precedes CD4 T Cell Depletion in HIV-Infected Malawian Adults
|
|---|---|
| Published in |
PLOS ONE, September 2011
|
| DOI | 10.1371/journal.pone.0025610 |
| Pubmed ID | |
| Authors |
Sarah J. Glennie, Enoch Sepako, David Mzinza, Visopo Harawa, David J. C. Miles, Kondwani C. Jambo, Stephen B. Gordon, Neil A. Williams, Robert S. Heyderman |
| Abstract |
Invasive pneumococcal disease (IPD) is a leading cause of morbidity and mortality in HIV-infected African adults. CD4 T cell depletion may partially explain this high disease burden but those with relatively preserved T cell numbers are still at increased risk of IPD. This study evaluated the extent of pneumococcal-specific T cell memory dysfunction in asymptomatic HIV infection early on in the evolution of the disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Denmark | 1 | 3% |
| Germany | 1 | 3% |
| South Africa | 1 | 3% |
| Unknown | 36 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 25% |
| Researcher | 5 | 13% |
| Student > Master | 5 | 13% |
| Student > Bachelor | 5 | 13% |
| Student > Doctoral Student | 3 | 8% |
| Other | 10 | 25% |
| Unknown | 2 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 25% |
| Medicine and Dentistry | 8 | 20% |
| Immunology and Microbiology | 5 | 13% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Social Sciences | 3 | 8% |
| Other | 7 | 18% |
| Unknown | 4 | 10% |