Title |
Muscle-Bound Primordial Stem Cells Give Rise to Myofiber-Associated Myogenic and Non-Myogenic Progenitors
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Published in |
PLOS ONE, October 2011
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DOI | 10.1371/journal.pone.0025605 |
Pubmed ID | |
Authors |
Elad Segev, Gabi Shefer, Rivka Adar, Noa Chapal-Ilani, Shalev Itzkovitz, Inna Horovitz, Yitzhak Reizel, Dafna Benayahu, Ehud Shapiro |
Abstract |
Myofiber cultures give rise to myogenic as well as to non-myogenic cells. Whether these myofiber-associated non-myogenic cells develop from resident stem cells that possess mesenchymal plasticity or from other stem cells such as mesenchymal stem cells (MSCs) remain unsolved. To address this question, we applied a method for reconstructing cell lineage trees from somatic mutations to MSCs and myogenic and non-myogenic cells from individual myofibers that were cultured at clonal density.Our analyses show that (i) in addition to myogenic progenitors, myofibers also harbor non-myogenic progenitors of a distinct, yet close, lineage; (ii) myofiber-associated non-myogenic and myogenic cells share the same muscle-bound primordial stem cells of a lineage distinct from bone marrow MSCs; (iii) these muscle-bound primordial stem-cells first part to individual muscles and then differentiate into myogenic and non-myogenic stem cells. |
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United States | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 17 | 100% |
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Researcher | 3 | 18% |
Student > Ph. D. Student | 3 | 18% |
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Professor > Associate Professor | 2 | 12% |
Other | 1 | 6% |
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Computer Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 2 | 12% |