| Title |
EGFR-Targeted Hybrid Plasmonic Magnetic Nanoparticles Synergistically Induce Autophagy and Apoptosis in Non-Small Cell Lung Cancer Cells
|
|---|---|
| Published in |
PLOS ONE, November 2011
|
| DOI | 10.1371/journal.pone.0025507 |
| Pubmed ID | |
| Authors |
Tomohisa Yokoyama, Justina Tam, Shinji Kuroda, Ailing W. Scott, Jesse Aaron, Tim Larson, Manish Shanker, Arlene M. Correa, Seiji Kondo, Jack A. Roth, Konstantin Sokolov, Rajagopal Ramesh |
| Abstract |
The epidermal growth factor receptor (EGFR) is overexpressed in 80% of non-small cell lung cancer (NSCLC) and is associated with poor survival. In recent years, EGFR-targeted inhibitors have been tested in the clinic for NSCLC. Despite the emergence of novel therapeutics and their application in cancer therapy, the overall survival rate of lung cancer patients remains 15%. To develop more effective therapies for lung cancer we have combined the anti-EGFR antibody (Clone 225) as a molecular therapeutic with hybrid plasmonic magnetic nanoparticles (NP) and tested on non-small cell lung cancer (NSCLC) cells. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Unknown | 64 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 26% |
| Researcher | 10 | 15% |
| Professor > Associate Professor | 6 | 9% |
| Student > Bachelor | 6 | 9% |
| Student > Master | 6 | 9% |
| Other | 11 | 17% |
| Unknown | 10 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 17% |
| Agricultural and Biological Sciences | 10 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 15% |
| Chemistry | 6 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Other | 13 | 20% |
| Unknown | 12 | 18% |