| Title |
A Test of the Coordinated Expression Hypothesis for the Origin and Maintenance of the GAL Cluster in Yeast
|
|---|---|
| Published in |
PLOS ONE, September 2011
|
| DOI | 10.1371/journal.pone.0025290 |
| Pubmed ID | |
| Authors |
Gregory I. Lang, David Botstein |
| Abstract |
Metabolic gene clusters--functionally related and physically clustered genes--are a common feature of some eukaryotic genomes. Two hypotheses have been advanced to explain the origin and maintenance of metabolic gene clusters: coordinated gene expression and genetic linkage. Here we test the hypothesis that selection for coordinated gene expression underlies the clustering of GAL genes in the yeast genome. We find that, although clustering coordinates the expression of GAL1 and GAL10, disrupting the GAL cluster does not impair fitness, suggesting that other mechanisms, such as genetic linkage, drive the origin and maintenance metabolic gene clusters. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 12 | 24% |
| United States | 7 | 14% |
| Australia | 3 | 6% |
| United Kingdom | 1 | 2% |
| Canada | 1 | 2% |
| Chile | 1 | 2% |
| Unknown | 24 | 49% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 37 | 76% |
| Scientists | 10 | 20% |
| Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 4% |
| Germany | 2 | 2% |
| Canada | 2 | 2% |
| Australia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| Slovenia | 1 | <1% |
| Unknown | 95 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 28% |
| Student > Ph. D. Student | 19 | 18% |
| Student > Bachelor | 9 | 8% |
| Student > Master | 8 | 7% |
| Professor > Associate Professor | 7 | 7% |
| Other | 20 | 19% |
| Unknown | 14 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 49 | 46% |
| Biochemistry, Genetics and Molecular Biology | 22 | 21% |
| Computer Science | 5 | 5% |
| Social Sciences | 4 | 4% |
| Nursing and Health Professions | 3 | 3% |
| Other | 11 | 10% |
| Unknown | 13 | 12% |