| Title |
Dicer1 Depletion in Male Germ Cells Leads to Infertility Due to Cumulative Meiotic and Spermiogenic Defects
|
|---|---|
| Published in |
PLOS ONE, October 2011
|
| DOI | 10.1371/journal.pone.0025241 |
| Pubmed ID | |
| Authors |
Yannick Romero, Oliver Meikar, Marilena D. Papaioannou, Béatrice Conne, Corinne Grey, Manuela Weier, François Pralong, Bernard De Massy, Henrik Kaessmann, Jean-Dominique Vassalli, Noora Kotaja, Serge Nef |
| Abstract |
Spermatogenesis is a complex biological process that requires a highly specialized control of gene expression. In the past decade, small non-coding RNAs have emerged as critical regulators of gene expression both at the transcriptional and post-transcriptional level. DICER1, an RNAse III endonuclease, is essential for the biogenesis of several classes of small RNAs, including microRNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs), but is also critical for the degradation of toxic transposable elements. In this study, we investigated to which extent DICER1 is required for germ cell development and the progress of spermatogenesis in mice. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 2 | 2% |
| South Africa | 1 | <1% |
| Finland | 1 | <1% |
| Russia | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 97 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 25% |
| Student > Ph. D. Student | 23 | 22% |
| Student > Master | 13 | 12% |
| Student > Doctoral Student | 6 | 6% |
| Student > Bachelor | 5 | 5% |
| Other | 18 | 17% |
| Unknown | 14 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 37% |
| Biochemistry, Genetics and Molecular Biology | 31 | 30% |
| Medicine and Dentistry | 11 | 10% |
| Neuroscience | 2 | 2% |
| Veterinary Science and Veterinary Medicine | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 15 | 14% |