| Title |
LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster
|
|---|---|
| Published in |
PLOS ONE, August 2011
|
| DOI | 10.1371/journal.pone.0024151 |
| Pubmed ID | |
| Authors |
Charcacia Sanders, Dean P. Smith |
| Abstract |
In animals, male fertility requires the successful development of motile sperm. During Drosophila melanogaster spermatogenesis, 64 interconnected spermatids descended from a single germline stem cell are resolved into motile sperm in a process termed individualization. Here we identify a putative double-stranded RNA binding protein LUMP that is required for male fertility. lump(1) mutants are male-sterile and lack motile sperm due to defects in sperm individualization. We show that one dsRNA binding domains (dsRBD) is essential for LUMP function in male fertility. These findings reveal LUMP is a novel factor required for late stages of male germline differentiation. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 4% |
| Germany | 1 | 4% |
| Unknown | 23 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 36% |
| Student > Ph. D. Student | 6 | 24% |
| Student > Master | 4 | 16% |
| Professor > Associate Professor | 2 | 8% |
| Student > Bachelor | 2 | 8% |
| Other | 1 | 4% |
| Unknown | 1 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 60% |
| Biochemistry, Genetics and Molecular Biology | 3 | 12% |
| Computer Science | 2 | 8% |
| Economics, Econometrics and Finance | 1 | 4% |
| Medicine and Dentistry | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 2 | 8% |