| Title |
A Stratified Transcriptomics Analysis of Polygenic Fat and Lean Mouse Adipose Tissues Identifies Novel Candidate Obesity Genes
|
|---|---|
| Published in |
PLOS ONE, September 2011
|
| DOI | 10.1371/journal.pone.0023944 |
| Pubmed ID | |
| Authors |
Nicholas M. Morton, Yvonne B. Nelson, Zoi Michailidou, Emma M. Di Rollo, Lynne Ramage, Patrick W. F. Hadoke, Jonathan R. Seckl, Lutz Bunger, Simon Horvat, Christopher J. Kenyon, Donald R. Dunbar |
| Abstract |
Obesity and metabolic syndrome results from a complex interaction between genetic and environmental factors. In addition to brain-regulated processes, recent genome wide association studies have indicated that genes highly expressed in adipose tissue affect the distribution and function of fat and thus contribute to obesity. Using a stratified transcriptome gene enrichment approach we attempted to identify adipose tissue-specific obesity genes in the unique polygenic Fat (F) mouse strain generated by selective breeding over 60 generations for divergent adiposity from a comparator Lean (L) strain. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 1% |
| South Africa | 1 | 1% |
| Mexico | 1 | 1% |
| Nigeria | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 90 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 23% |
| Student > Ph. D. Student | 20 | 21% |
| Student > Master | 13 | 14% |
| Professor | 7 | 7% |
| Student > Bachelor | 5 | 5% |
| Other | 19 | 20% |
| Unknown | 9 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 42 | 44% |
| Medicine and Dentistry | 13 | 14% |
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Unspecified | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 19 | 20% |