| Title |
Activation of the Wnt/β-Catenin Signaling Pathway by Mechanical Ventilation Is Associated with Ventilator-Induced Pulmonary Fibrosis in Healthy Lungs
|
|---|---|
| Published in |
PLOS ONE, September 2011
|
| DOI | 10.1371/journal.pone.0023914 |
| Pubmed ID | |
| Authors |
Jesús Villar, Nuria E. Cabrera, Francisco Valladares, Milena Casula, Carlos Flores, Lluís Blanch, María Elisa Quilez, Norberto Santana-Rodríguez, Robert M. Kacmarek, Arthur S. Slutsky |
| Abstract |
Mechanical ventilation (MV) with high tidal volumes (V(T)) can cause or aggravate lung damage, so-called ventilator induced lung injury (VILI). The relationship between specific mechanical events in the lung and the cellular responses that result in VILI remains incomplete. Since activation of Wnt/β-catenin signaling has been suggested to be central to mechanisms of lung healing and fibrosis, we hypothesized that the Wnt/β-catenin signaling plays a role during VILI. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 13% |
| Researcher | 5 | 13% |
| Other | 4 | 10% |
| Unspecified | 4 | 10% |
| Professor > Associate Professor | 4 | 10% |
| Other | 12 | 30% |
| Unknown | 6 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 20% |
| Biochemistry, Genetics and Molecular Biology | 7 | 18% |
| Unspecified | 4 | 10% |
| Medicine and Dentistry | 4 | 10% |
| Nursing and Health Professions | 2 | 5% |
| Other | 8 | 20% |
| Unknown | 7 | 18% |