Report for: Association Analysis of Canonical Wnt Signalling Genes in Diabetic Nephropathy

Title	Association Analysis of Canonical Wnt Signalling Genes in Diabetic Nephropathy
Published in	PLOS ONE, August 2011
DOI	10.1371/journal.pone.0023904
Pubmed ID	21876774
Authors	David H. Kavanagh, David A. Savage, Christopher C. Patterson, Amy Jayne McKnight, John K. Crean, Alexander P. Maxwell, Gareth J. McKay
Abstract	Several studies have provided compelling evidence implicating the Wnt signalling pathway in the pathogenesis of diabetic nephropathy. Gene expression profiles associated with renal fibrosis have been attenuated through Wnt pathway modulation in model systems implicating Wnt pathway members as potential therapeutic targets for the treatment of diabetic nephropathy. We assessed tag and potentially functional single nucleotide polymorphisms (SNPs; n = 31) in four key Wnt pathway genes (CTNNB1, AXIN2, LRP5 and LRP6) for association with diabetic nephropathy using a case-control design.

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Other	1	2%
Unknown	12	27%

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