| Title |
Longevity in Mice Is Promoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production
|
|---|---|
| Published in |
PLOS ONE, August 2011
|
| DOI | 10.1371/journal.pone.0023652 |
| Pubmed ID | |
| Authors |
Mitsuharu Matsumoto, Shin Kurihara, Ryoko Kibe, Hisashi Ashida, Yoshimi Benno |
| Abstract |
Chronic low-grade inflammation is recognized as an important factor contributing to senescence and age-related diseases. In mammals, levels of polyamines (PAs) decrease during the ageing process; PAs are known to decrease systemic inflammation by inhibiting inflammatory cytokine synthesis in macrophages. Reductions in intestinal luminal PAs levels have been associated with intestinal barrier dysfunction. The probiotic strain Bifidobacterium animalis subsp. lactis LKM512 is known to increase intestinal luminal PA concentrations. |
X Demographics
The data shown below were collected from the profiles of 56 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 23% |
| Japan | 6 | 11% |
| Australia | 1 | 2% |
| United Kingdom | 1 | 2% |
| Brazil | 1 | 2% |
| Hong Kong | 1 | 2% |
| Unknown | 33 | 59% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 49 | 88% |
| Practitioners (doctors, other healthcare professionals) | 4 | 7% |
| Scientists | 3 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 281 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | <1% |
| United Kingdom | 1 | <1% |
| Brazil | 1 | <1% |
| Argentina | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 275 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 64 | 23% |
| Student > Master | 40 | 14% |
| Student > Ph. D. Student | 34 | 12% |
| Student > Bachelor | 27 | 10% |
| Professor > Associate Professor | 13 | 5% |
| Other | 41 | 15% |
| Unknown | 62 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 97 | 35% |
| Biochemistry, Genetics and Molecular Biology | 35 | 12% |
| Medicine and Dentistry | 27 | 10% |
| Immunology and Microbiology | 14 | 5% |
| Neuroscience | 6 | 2% |
| Other | 32 | 11% |
| Unknown | 70 | 25% |