| Title |
RIP1-Dependent and Independent Effects of Necrostatin-1 in Necrosis and T Cell Activation
|
|---|---|
| Published in |
PLOS ONE, August 2011
|
| DOI | 10.1371/journal.pone.0023209 |
| Pubmed ID | |
| Authors |
YoungSik Cho, Thomas McQuade, Haibing Zhang, Jianke Zhang, Francis Ka-Ming Chan |
| Abstract |
Programmed necrosis/necroptosis is an emerging form of cell death that plays important roles in mammalian development and the immune system. The pro-necrotic kinases in the receptor interacting protein (RIP) family are crucial mediators of programmed necrosis. Recent advances in necrosis research have been greatly aided by the identification of chemical inhibitors that block programmed necrosis. Necrostatin-1 (Nec-1) and its derivatives were previously shown to target the pro-necrotic kinase RIP1/RIPK1. The protective effect conferred by Nec-1 and its derivatives in many experimental model systems was often attributed to the inhibition of RIP1 function. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Belgium | 2 | 1% |
| Brazil | 2 | 1% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Hungary | 1 | <1% |
| France | 1 | <1% |
| Other | 3 | 2% |
| Unknown | 136 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 24% |
| Researcher | 31 | 20% |
| Student > Master | 19 | 13% |
| Student > Bachelor | 16 | 11% |
| Student > Doctoral Student | 9 | 6% |
| Other | 25 | 16% |
| Unknown | 16 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 45% |
| Medicine and Dentistry | 18 | 12% |
| Biochemistry, Genetics and Molecular Biology | 18 | 12% |
| Chemistry | 8 | 5% |
| Immunology and Microbiology | 8 | 5% |
| Other | 10 | 7% |
| Unknown | 21 | 14% |