| Title |
Human Mesenchymal Stem Cells Prolong Survival and Ameliorate Motor Deficit through Trophic Support in Huntington's Disease Mouse Models
|
|---|---|
| Published in |
PLOS ONE, August 2011
|
| DOI | 10.1371/journal.pone.0022924 |
| Pubmed ID | |
| Authors |
Yuan-Ta Lin, Yijuang Chern, Che-Kun James Shen, Hsin-Lan Wen, Ya-Chin Chang, Hung Li, Tzu-Hao Cheng, Hsiu Mei Hsieh-Li |
| Abstract |
We investigated the therapeutic potential of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) in Huntington's disease (HD) mouse models. Ten weeks after intrastriatal injection of quinolinic acid (QA), mice that received hBM-MSC transplantation showed a significant reduction in motor function impairment and increased survival rate. Transplanted hBM-MSCs were capable of survival, and inducing neural proliferation and differentiation in the QA-lesioned striatum. In addition, the transplanted hBM-MSCs induced microglia, neuroblasts and bone marrow-derived cells to migrate into the QA-lesioned region. Similar results were obtained in R6/2-J2, a genetically-modified animal model of HD, except for the improvement of motor function. After hBM-MSC transplantation, the transplanted hBM-MSCs may integrate with the host cells and increase the levels of laminin, Von Willebrand Factor (VWF), stromal cell-derived factor-1 (SDF-1), and the SDF-1 receptor Cxcr4. The p-Erk1/2 expression was increased while Bax and caspase-3 levels were decreased after hBM-MSC transplantation suggesting that the reduced level of apoptosis after hBM-MSC transplantation was of benefit to the QA-lesioned mice. Our data suggest that hBM-MSCs have neural differentiation improvement potential, neurotrophic support capability and an anti-apoptotic effect, and may be a feasible candidate for HD therapy. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Unknown | 107 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 20% |
| Researcher | 17 | 15% |
| Student > Bachelor | 13 | 12% |
| Student > Master | 11 | 10% |
| Student > Doctoral Student | 9 | 8% |
| Other | 20 | 18% |
| Unknown | 18 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 21 | 19% |
| Agricultural and Biological Sciences | 20 | 18% |
| Medicine and Dentistry | 20 | 18% |
| Biochemistry, Genetics and Molecular Biology | 10 | 9% |
| Nursing and Health Professions | 3 | 3% |
| Other | 16 | 15% |
| Unknown | 20 | 18% |