| Title |
MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus
|
|---|---|
| Published in |
PLOS ONE, August 2011
|
| DOI | 10.1371/journal.pone.0022839 |
| Pubmed ID | |
| Authors |
Dwi Setyowati Karolina, Arunmozhiarasi Armugam, Subramaniam Tavintharan, Michael T. K. Wong, Su Chi Lim, Chee Fang Sum, Kandiah Jeyaseelan |
| Abstract |
Dysregulation of microRNA (miRNA) expression in various tissues and body fluids has been demonstrated to be associated with several diseases, including Type 2 Diabetes mellitus (T2D). Here, we compare miRNA expression profiles in different tissues (pancreas, liver, adipose and skeletal muscle) as well as in blood samples from T2D rat model and highlight the potential of circulating miRNAs as biomarkers of T2D. In parallel, we have examined the expression profiles of miRNAs in blood samples from Impaired Fasting Glucose (IFG) and T2D male patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 289 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| United Kingdom | 2 | <1% |
| Nepal | 1 | <1% |
| India | 1 | <1% |
| Singapore | 1 | <1% |
| Hungary | 1 | <1% |
| Spain | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 276 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 65 | 22% |
| Researcher | 44 | 15% |
| Student > Master | 36 | 12% |
| Student > Bachelor | 28 | 10% |
| Professor > Associate Professor | 14 | 5% |
| Other | 45 | 16% |
| Unknown | 57 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 85 | 29% |
| Biochemistry, Genetics and Molecular Biology | 61 | 21% |
| Medicine and Dentistry | 38 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 3% |
| Neuroscience | 6 | 2% |
| Other | 22 | 8% |
| Unknown | 69 | 24% |