| Title |
Novel Automated Blood Separations Validate Whole Cell Biomarkers
|
|---|---|
| Published in |
PLOS ONE, July 2011
|
| DOI | 10.1371/journal.pone.0022430 |
| Pubmed ID | |
| Authors |
Douglas E. Burger, Limei Wang, Liqin Ban, Yoshiaki Okubo, Willem M. Kühtreiber, Ashley K. Leichliter, Denise L. Faustman |
| Abstract |
Progress in clinical trials in infectious disease, autoimmunity, and cancer is stymied by a dearth of successful whole cell biomarkers for peripheral blood lymphocytes (PBLs). Successful biomarkers could help to track drug effects at early time points in clinical trials to prevent costly trial failures late in development. One major obstacle is the inaccuracy of Ficoll density centrifugation, the decades-old method of separating PBLs from the abundant red blood cells (RBCs) of fresh blood samples. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 8% |
| Denmark | 1 | 4% |
| Unknown | 23 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 27% |
| Other | 6 | 23% |
| Professor > Associate Professor | 2 | 8% |
| Student > Master | 2 | 8% |
| Lecturer | 1 | 4% |
| Other | 3 | 12% |
| Unknown | 5 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 35% |
| Medicine and Dentistry | 3 | 12% |
| Immunology and Microbiology | 2 | 8% |
| Economics, Econometrics and Finance | 2 | 8% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Other | 3 | 12% |
| Unknown | 6 | 23% |