| Title |
Overexpression of Human and Fly Frataxins in Drosophila Provokes Deleterious Effects at Biochemical, Physiological and Developmental Levels
|
|---|---|
| Published in |
PLOS ONE, July 2011
|
| DOI | 10.1371/journal.pone.0021017 |
| Pubmed ID | |
| Authors |
Juan A. Navarro, José V. Llorens, Sirena Soriano, José A. Botella, Stephan Schneuwly, María J. Martínez-Sebastián, María D. Moltó |
| Abstract |
Friedreich's ataxia (FA), the most frequent form of inherited ataxias in the Caucasian population, is caused by a reduced expression of frataxin, a highly conserved protein. Model organisms have contributed greatly in the efforts to decipher the function of frataxin; however, the precise function of this protein remains elusive. Overexpression studies are a useful approach to investigate the mechanistic actions of frataxin; however, the existing literature reports contradictory results. To further investigate the effect of frataxin overexpression, we analyzed the consequences of overexpressing human (FXN) and fly (FH) frataxins in Drosophila. |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| United States | 1 | 2% |
| Korea, Republic of | 1 | 2% |
| Unknown | 63 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 36% |
| Researcher | 10 | 15% |
| Student > Bachelor | 7 | 11% |
| Professor > Associate Professor | 5 | 8% |
| Student > Doctoral Student | 3 | 5% |
| Other | 10 | 15% |
| Unknown | 7 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 41% |
| Biochemistry, Genetics and Molecular Biology | 16 | 24% |
| Neuroscience | 7 | 11% |
| Chemistry | 4 | 6% |
| Medicine and Dentistry | 3 | 5% |
| Other | 1 | 2% |
| Unknown | 8 | 12% |