| Title |
Nicotinic Acid Receptor Abnormalities in Human Skin Cancer: Implications for a Role in Epidermal Differentiation
|
|---|---|
| Published in |
PLOS ONE, May 2011
|
| DOI | 10.1371/journal.pone.0020487 |
| Pubmed ID | |
| Authors |
Yira Bermudez, Claudia A. Benavente, Ralph G. Meyer, W. Russell Coyle, Myron K. Jacobson, Elaine L. Jacobson |
| Abstract |
Chronic UV skin exposure leads to epidermal differentiation defects in humans that can be largely restored by pharmacological doses of nicotinic acid. Nicotinic acid has been identified as a ligand for the human G-protein-coupled receptors GPR109A and GPR109B that signal through G(i)-mediated inhibition of adenylyl cyclase. We have examined the expression, cellular distribution, and functionality of GPR109A/B in human skin and skin derived epidermal cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Unknown | 41 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 26% |
| Student > Ph. D. Student | 8 | 19% |
| Student > Master | 4 | 10% |
| Student > Bachelor | 3 | 7% |
| Student > Doctoral Student | 2 | 5% |
| Other | 7 | 17% |
| Unknown | 7 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 29% |
| Biochemistry, Genetics and Molecular Biology | 9 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Medicine and Dentistry | 3 | 7% |
| Computer Science | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 10 | 24% |