Title |
HIVToolbox, an Integrated Web Application for Investigating HIV
|
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Published in |
PLOS ONE, May 2011
|
DOI | 10.1371/journal.pone.0020122 |
Pubmed ID | |
Authors |
David Sargeant, Sandeep Deverasetty, Yang Luo, Angel Villahoz Baleta, Stephanie Zobrist, Viraj Rathnayake, Jacqueline C. Russo, Jay Vyas, Mark A. Muesing, Martin R. Schiller |
Abstract |
Many bioinformatic databases and applications focus on a limited domain of knowledge federating links to information in other databases. This segregated data structure likely limits our ability to investigate and understand complex biological systems. To facilitate research, therefore, we have built HIVToolbox, which integrates much of the knowledge about HIV proteins and allows virologists and structural biologists to access sequence, structure, and functional relationships in an intuitive web application. HIV-1 integrase protein was used as a case study to show the utility of this application. We show how data integration facilitates identification of new questions and hypotheses much more rapid and convenient than current approaches using isolated repositories. Several new hypotheses for integrase were created as an example, and we experimentally confirmed a predicted CK2 phosphorylation site. Weblink: [http://hivtoolbox.bio-toolkit.com]. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 4% |
United States | 1 | 4% |
Portugal | 1 | 4% |
Argentina | 1 | 4% |
Unknown | 22 | 85% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 27% |
Student > Bachelor | 5 | 19% |
Student > Ph. D. Student | 4 | 15% |
Other | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Other | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 38% |
Computer Science | 5 | 19% |
Medicine and Dentistry | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Engineering | 2 | 8% |
Other | 4 | 15% |