| Title |
Insulin Resistance in Non-Obese Subjects Is Associated with Activation of the JNK Pathway and Impaired Insulin Signaling in Skeletal Muscle
|
|---|---|
| Published in |
PLOS ONE, May 2011
|
| DOI | 10.1371/journal.pone.0019878 |
| Pubmed ID | |
| Authors |
Umesh B. Masharani, Betty A. Maddux, Xiaojuan Li, Giorgos K. Sakkas, Kathleen Mulligan, Morris Schambelan, Ira D. Goldfine, Jack F. Youngren |
| Abstract |
The pathogenesis of insulin resistance in the absence of obesity is unknown. In obesity, multiple stress kinases have been identified that impair the insulin signaling pathway via serine phosphorylation of key second messenger proteins. These stress kinases are activated through various mechanisms related to lipid oversupply locally in insulin target tissues and in various adipose depots. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Egypt | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Germany | 2 | 3% |
| Ireland | 1 | 2% |
| Switzerland | 1 | 2% |
| Unknown | 52 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 19% |
| Student > Postgraduate | 6 | 10% |
| Student > Master | 6 | 10% |
| Researcher | 4 | 7% |
| Professor > Associate Professor | 4 | 7% |
| Other | 15 | 26% |
| Unknown | 12 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 33% |
| Agricultural and Biological Sciences | 13 | 22% |
| Engineering | 3 | 5% |
| Neuroscience | 2 | 3% |
| Nursing and Health Professions | 1 | 2% |
| Other | 9 | 16% |
| Unknown | 11 | 19% |