| Title |
Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation
|
|---|---|
| Published in |
PLOS ONE, June 2011
|
| DOI | 10.1371/journal.pone.0019783 |
| Pubmed ID | |
| Authors |
Hyunmi Lee, Jimmy A. Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C. Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick |
| Abstract |
Evidence indicates that Bax functions as a "lipidic" pore to regulate mitochondrial outer membrane permeabilization (MOMP), the apoptosis commitment step, through unknown membrane elements. Here we show mitochondrial ceramide elevation facilitates MOMP-mediated cytochrome c release in HeLa cells by generating a previously-unrecognized mitochondrial ceramide-rich macrodomain (MCRM), which we visualize and isolate, into which Bax integrates. |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | 2% |
| Japan | 2 | 2% |
| Austria | 1 | 1% |
| Finland | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 82 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 27% |
| Researcher | 20 | 22% |
| Student > Master | 12 | 13% |
| Student > Bachelor | 5 | 6% |
| Professor | 4 | 4% |
| Other | 11 | 12% |
| Unknown | 13 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 44% |
| Biochemistry, Genetics and Molecular Biology | 21 | 24% |
| Medicine and Dentistry | 5 | 6% |
| Chemistry | 3 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Other | 4 | 4% |
| Unknown | 16 | 18% |