| Title |
Genome-Wide DNA Methylation Analysis Reveals Phytoestrogen Modification of Promoter Methylation Patterns during Embryonic Stem Cell Differentiation
|
|---|---|
| Published in |
PLOS ONE, April 2011
|
| DOI | 10.1371/journal.pone.0019278 |
| Pubmed ID | |
| Authors |
Noriko Sato, Naomi Yamakawa, Moe Masuda, Katsuko Sudo, Izuho Hatada, Masaaki Muramatsu |
| Abstract |
Environmental challenges during development affect the fetal epigenome, but the period(s) vulnerable to epigenetic dysregulation is(are) not clear. By employing a soy phytoestrogen, genistein, that is known to alter the epigenetic states of the A(vy) allele during embryogenesis, we have explored the sensitive period for epigenetic regulation. The post-implantation period, when de novo DNA methylation actively proceeds, is amenable to in vitro analysis using a mouse embryonic stem (ES) cell differentiation system. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 4% |
| Germany | 1 | 2% |
| Uruguay | 1 | 2% |
| Italy | 1 | 2% |
| Mexico | 1 | 2% |
| Japan | 1 | 2% |
| Unknown | 40 | 85% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 17% |
| Student > Master | 7 | 15% |
| Researcher | 6 | 13% |
| Student > Ph. D. Student | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Other | 11 | 23% |
| Unknown | 6 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 47% |
| Biochemistry, Genetics and Molecular Biology | 6 | 13% |
| Medicine and Dentistry | 6 | 13% |
| Environmental Science | 3 | 6% |
| Nursing and Health Professions | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 7 | 15% |