Title |
Three-Dimensional cryoEM Reconstruction of Native LDL Particles to 16Å Resolution at Physiological Body Temperature
|
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Published in |
PLOS ONE, May 2011
|
DOI | 10.1371/journal.pone.0018841 |
Pubmed ID | |
Authors |
Vibhor Kumar, Sarah J. Butcher, Katariina Öörni, Peter Engelhardt, Jukka Heikkonen, Kimmo Kaski, Mika Ala-Korpela, Petri T. Kovanen |
Abstract |
Low-density lipoprotein (LDL) particles, the major carriers of cholesterol in the human circulation, have a key role in cholesterol physiology and in the development of atherosclerosis. The most prominent structural components in LDL are the core-forming cholesteryl esters (CE) and the particle-encircling single copy of a huge, non-exchangeable protein, the apolipoprotein B-100 (apoB-100). The shape of native LDL particles and the conformation of native apoB-100 on the particles remain incompletely characterized at the physiological human body temperature (37 °C). |
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